Monthly Archives: September 2020

D-Wave Takes Giant Leap in Computing with Advantage

Everyone in computing is familiar with the idea of Moore's Law, that computing power doubles every two years, but quantum computing could be making that premise a bit of an anachronism. Recently growth in the field of quantum computing has been accelerating at a rate that makes this seem like an antiquated adage of a simpler time.

This is especially evident in the news this week that D-Wave systems have released the first quantum computer designed to be used in commercial applications, The Advantage. The Advantage features 5000 connected qubits, a number that Frederic Lardinois from TechCrunch notes is over 2.5 times as large as their previous offering of 2000 connected qubits. This larger hardware is able to interconnect 15 interconnections simultaneously versus utilizing 6 interconnections in previous iterations.

These changes create a massive explosion in the computing power offered by the Advantage computer, giving it the ability to handle up to 1 million independent variables. Using their advanced Pegasus chip to link qubits, the computer is able to natively solve problems with between 600-800 variables, providing for a wide variety of commercial applications. As D-Wave CEO Alan Baratz told Emil Protalinski of Venture Beat, "There is no other quantum computer anywhere in the world that can solve problems at the scale and complexity that this quantum computer can solve problems. It really is the only one that you can run real business applications on. The other quantum computers are primarily prototypes. You can do experimentation, run small proofs of concept, but none of them can support applications at the scale that we can.

Putting computing power like this in the hands of innovators, researchers, and companies that are seeking to solve previously unsolvable problems is tremendously empowering. POLARISqb will have the ability to utilize platforms like the Advantage to power chemical and molecular searches on a scale that was previously unfathomable in the industry, optimizing the pace of drug discovery in ways never seen in the biotech and pharmaceutical industries. With the pace of innovation in the world of quantum expected to continue and accelerate, it is our goal to make molecular analysis and protein targeting faster than ever before, developing the ability to provide treatments and cures for all diseases and all people.

Innovations in BioPharma Book
The PolarisQB logo over an image of a hand holding a molecule.Quantum computing is changing the world, and carries with it potential to revolutionize many industries; from finance, to logistics, to our ability to fight infectious disease. While the promise of this technology is tremendous, currently it faces challenges of scalability and applicability that make it both difficult to implement and commercially unviable. This is where Polarisqb  stands apart in the world of quantum drug discovery, bringing market-ready methods that utilize quantum-inspired computing to accelerate the identification of potential molecular assets by up to 90%.  This technology can narrow the potential field of candidate molecules from billions to dozens in about the same amount of time that it takes to complete a traditional internet search.
In partnership with Fujitsu Global, we have used the Digital Annealer, a groundbreaking, quantum-inspired technology, to optimize single or multiple objective searches. The Digital Annealer uses heuristic approaches, rather than brute force, to efficiently search very large chemical spaces with unparalleled speed.  As a case study, Polarisqb set the objective of  identifying potential candidates to treat Dengue Fever, a mosquito borne viral disease that threatens up to 40% of the world population with potentially deadly complications. There is no cure for Dengue Fever, and the current vaccine is effective only for people previously infected, as it may increase risks of severe infections to healthy patients. Polarisqb engineers and chemists targeted the RNA-dependent RNA polymerase protein in the Dengue virus and developed a chemical library of over 1 billion molecules. Once this chemical library was constructed, we used the Digital Annealer to identify 977 potential drug candidates from the over billion molecules in the library. We filter out molecules with un-drug-like properties using AI/ML-based algorithms and accurately calculate binding affinity using QM/MM. This process of rapid combinatorial enumeration and the use of more accurate calculations to scan massive libraries has the potential to identify cures to many diseases that are currently untreatable in a fraction of the time and resources required for the traditional drug discovery process.Polarisqb is at the cutting edge of the world of drug discovery, slashing timeframes and costs of discovery processes multiple times over. As we continue to grow, the potential applications for this technology will change the world by developing treatments for previously incurable diseases and pandemics, revolutionizing drug discovery with quantum solutions never before used in the biopharmaceutical industry.
Quantum Tech for Healthcare (August 2020)

Our CEO, Dr. Shahar Kienan was recently a member of a panel on Quantum Tech for Healthcare hosted by Dave Snelling of Fujitsu Global. The session featured presentations by Dr. Frederik Flother from IBM, Hans Melo of, and Nihil Khaine of ApexBit on how quantum technology is being utilized in the healthcare field.

We are applying quantum computing to the world of drug discovery, accelerating the process by utilizing heuristic computing such as annealing to identify potential treatment molecules for a wide variety of diseases and ailments.